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July 12, 2026BMC PediatricsOpen Access

Association of Aggregate Index of Systemic Inflammation (AISI) with all-cause mortality in critically Ill pediatric patients: a retrospective cohort study

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Authors

DTDe-Chun TianXZXiaolan ZhangCCC F Chen

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Overview

Retrospective cohort study assesses AISI's link to mortality in critically ill pediatric patients, suggesting implications for prognosis.

Key Points

  • This research aims to clarify the connection between AISI and all-cause mortality in critically ill pediatric patients.
  • Retrospective analysis of 8,797 patients from the PIC Database
  • AISI was log₂-transformed and categorized into quartiles
  • Cox proportional hazards regression and threshold effect analysis were utilized.
  • Overall 28-day in-hospital mortality rate was 4.3% and ICU mortality rate was 4.2%.
  • Significant nonlinear association found between log₂-transformed AISI and mortality outcomes.
  • Threshold points identified at 5.410 and 5.407 for in-hospital and ICU mortality, respectively.

Cite This Study

Tian et al. (2026) studied this question.

synapsesocial.com/papers/6a5333754f7abc118adee047https://doi.org/10.1186/s12887-026-07305-4
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