An 8-month combined strength and aerobic exercise program improved total cholesterol (-9.4%), triglycerides (-18.6%), HDL-C (+5.2%), and apo-A1 (+11.2%) in CAD patients (P<.05).
Does a combined strength and aerobic exercise program improve blood lipids and muscular strength in patients with coronary artery disease, and are these effects maintained after detraining?
A combined strength and aerobic exercise program improves lipid profiles and muscular strength in CAD patients, but these benefits are lost after 3 months of detraining, highlighting the need for continuous lifelong exercise.
p-value: p=<.05
PURPOSE: The aim of this study was to investigate training and detraining effects on blood lipids and apolipoproteins induced by a specific program that combined strength and aerobic exercise in patients with coronary artery disease (CAD). METHODS: For this study, 14 patients participated in a supervised 8-month training program composed of two strength sessions (60% of 1 repetition maximum) and two aerobic training sessions (60%-85% of maximum heart rate), and 13 patients served as a control group. Blood samples for total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), apolipoproteins A1 (apo-A1) and B (apo-B), and lipoprotein (a) (Lpa) were obtained along with muscular strength at the beginning of the study, after 4 and 8 months of training and after 3 months of detraining. RESULTS: The patients in the intervention group showed favorable alterations after 8 months of training (TC, -9.4; TG, -18.6; HDL-C, 5.2; apo-A1, 11.2%; P <.05), but these were reversed after 3 months of detraining (TC, +3.7; TG, 16.1; HDL-C, -3.6; apo-A1, -5.5%). In addition, body strength also improved after training (27.8%) but reversed (-12.9%) after detraining (P <.05). The patients in the control group did not experience any significant alterations. CONCLUSIONS: The results indicate that an 8-month training program combining strength and aerobic exercise induces favorable muscular and biochemical adaptations, on TC, TG, HDL-C, and apo-A1 levels, protecting patients with CAD. After 3 months of detraining, however, the favorable adaptations were reversed, underscoring the need of uninterrupted exercise throughout life.
Tokmakidis et al. (Thu,) conducted a other in Coronary artery disease (CAD) (n=27). Combined strength and aerobic exercise program vs. Control group was evaluated on Blood lipids and apolipoproteins (TC, TG, HDL-C, apo-A1, apo-B, and Lp[a]) (p=<.05). An 8-month combined strength and aerobic exercise program improved total cholesterol (-9.4%), triglycerides (-18.6%), HDL-C (+5.2%), and apo-A1 (+11.2%) in CAD patients (P<.05).