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April 14, 2006BloodOpen Access

Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia

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SBStephen BreitBoston Children's HospitalMSMartin StanullaLeibniz University HannoverTFThomas FlohrPraxis für Hämatologie und Onkologie

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Breit et al. (2006) studied this question.

synapsesocial.com/papers/6a10cabd497e609eda6456e4https://doi.org/10.1182/blood-2005-12-4956
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development2004 · 237 citations
  2. 2The Notch1 receptor is cleaved constitutively by a furin-like convertase1998 · 738 citations
  3. 3In vitro susceptibility to dexamethasone- and doxorubicin-induced apoptotic cell death in context of maturation stage, responsiveness to interleukin 7, and early cytoreduction in vivo in childhood T-cell acute lymphoblastic leukemia2002 · 41 citations
  4. 4Rationale and design of Total Therapy Study XV for newly diagnosed childhood acute lymphoblastic leukemia.2004 · 366 citations
  5. 5T cell acute lymphoblastic leukemia/lymphoma: a human cancer commonly associated with aberrant NOTCH1 signaling2004 · 100 citations