Key result
Radiofrequency ablation resulted in higher mean platelet volume and lower platelet counts one month post-procedure compared with baseline values.
Why the study?
Radiofrequency ablation may increase the risk of thromboembolic events, motivating an evaluation of its effect on mean platelet volume as an indicator of platelet activity.
Does radiofrequency ablation increase mean platelet volume in patients undergoing the procedure?
Observational (n=178)
Does radiofrequency ablation increase mean platelet volume in patients undergoing the procedure?
Radiofrequency ablation is associated with an increase in mean platelet volume at one month, suggesting increased platelet activity which may relate to thromboembolic risk.
Answers are grounded in this paper and cite their sources.
May signal heightened platelet reactivity post-ablation; hypothesis-generating for thromboembolic risk, needs prospective validation.
OBJECTIVE: Radiofrequency ablation (RFA) may increase the risk of thromboembolic events. The objective of this study was to evaluate the effect of RFA on mean platelet volume (MPV), an indicator of platelet activity. METHODS: A total of 95 patients undergoing RFA were included in the study. MPV was measured before and one month after the procedure. The control group was formed by 83 individuals of the same sex and age as those in the study group. RESULTS: Beta-blockers, non-dihydropyridine calcium channel blockers, and acetylsalicylic acid use was higher in the ablation group compared with the control group. Other baseline clinical characteristics and baseline hemoglobin, white blood cell count, platelet count, and MPV values were similar between the ablation and control groups. In the ablation group, baseline and post-procedural hemoglobin, white blood cell counts were similar. However, postprocedural MPV values were higher, and platelet counts were lower compared with the preprocedural values. CONCLUSION: Our results indicate that MPV values are higher after RFA compared with baseline values.
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Fatih Aksoy (2019) conducted an observational in Patients undergoing radiofrequency ablation (n=178). Radiofrequency ablation (RFA) vs. Age- and sex-matched control group was evaluated on Mean platelet volume (MPV). Radiofrequency ablation resulted in higher mean platelet volume and lower platelet counts one month post-procedure compared with baseline values.
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