Key result
Radiofrequency ablation is linked to a ~3-fold post-procedure increase in D-dimer levels.
Why the study?
The influence of radiofrequency ablation on changes in the coagulation system in patients with cardiac arrhythmias was not well characterized.
Does radiofrequency ablation alter the coagulation system in patients with cardiac arrhythmias?
Observational (n=30)
No
Does radiofrequency ablation alter the coagulation system in patients with cardiac arrhythmias?
Radiofrequency ablation for cardiac arrhythmias induces a prothrombotic state characterized by increased platelet aggregation, fibrinogen, and D-dimer levels up to 72 hours post-procedure.
Answers are grounded in this paper and cite their sources.
May warrant periprocedural thrombosis vigilance in arrhythmia ablation; leaves open whether D-dimer changes alter clinical outcomes or management.
OBJECTIVE: To determine an influence of radiofrequency ablation on changes in coagulation system. MATERIAL AND METHODS: We investigated 30 patients with cardiac arrhythmias. Platelet aggregation, fibrinogen and D-dimer level were analyzed before, right after, 24 and 72 h after radiofrequency ablation. Platelet aggregation was explored in whole blood and platelet-rich plasma using adenosine diphosphate (ADP), epinephrine, and collagen for induction. RESULTS: Platelet aggregation induced by ADP and collagen in whole blood plasma increased significantly (P<0.01) (by 45% and 43%, respectively) in 24 h after radiofrequency ablation and remained increased in 72 h after radiofrequency ablation (by 11% and 35%, respectively) (P<0.01) as compared with baseline results. Spontaneous aggregation of platelet-rich plasma as well as ADP- and collagen-induced platelet aggregation tended to decrease right after radiofrequency ablation. Epinephrine-induced platelet aggregation significantly decreased by 17.5% after radiofrequency ablation (P<0.01) and started to increase in 24 h after radiofrequency ablation. In 72 h after radiofrequency ablation, platelet aggregation induced by different agonists increased by 7-45% significantly (P<0.05), and values were higher than baseline ones. Fibrinogen level after radiofrequency ablation did not differ from that of the baseline (3.08+/-0.7 g/L), but D-dimer level increased significantly (from 0.39+/-0.3 to 1.29+/-2.4 mg/L, P<0.01). In 24 h after radiofrequency ablation, an increase in fibrinogen level and a decrease in D-dimer level were found. Fibrinogen level increased to 3.32+/-0.6 g/L significantly in 72 h after radiofrequency ablation (P<0.05). Meanwhile, D-dimer concentration decreased to 0.78+/-0.8 mg/L, but it was still significantly higher (P<0.05) than the baseline value. CONCLUSION: Despite diminished platelet aggregation and increased D-dimer level right after radiofrequency ablation, a risk of thrombosis increased in the next few days after radiofrequency ablation.
No takes yet. Share an insight, caveat, or question.
Kozlovaitė et al. (2009) conducted an observational in Cardiac arrhythmias (n=30). Radiofrequency ablation vs. Baseline (pre-ablation) was evaluated on D-dimer level immediately after radiofrequency ablation (p=<0.01). Radiofrequency ablation significantly increased D-dimer levels from 0.39 mg/L at baseline to 1.29 mg/L immediately post-procedure, indicating an increased risk of thrombosis.
Synapse has enriched 10 related papers. Consider them for comparative context: