Key result
PCSK9i initiation within 30 days post-MACE is linked to a ~70% reduction in subsequent MACE.
Why the study?
The timing of initiating PCSK9 inhibitor monoclonal antibody therapy and its impact on cardiovascular outcomes following a major adverse cardiovascular event was unknown.
Does earlier initiation of PCSK9 inhibitor monoclonal antibody therapy reduce the rate of subsequent MACE in adult patients with a prior cardiovascular event?
Cohort (n=58,997)
Does earlier initiation of PCSK9 inhibitor monoclonal antibody therapy reduce the rate of subsequent MACE in adult patients with a prior cardiovascular event?
Effect estimate: 70% reduction (within 30 days)
p-value: p=<0.0001
Earlier initiation of PCSK9 inhibitor therapy after a major adverse cardiovascular event is associated with a greater reduction in the rate of subsequent cardiovascular events.
Supports earlier PCSK9i mAb initiation post-MACE; hypothesis-generating and requires RCT confirmation.
Purpose: Timing of initiation of proprotein convertase subtilisin/kexin type 9 inhibitor (PCSK9i) monoclonal antibody (mAb) therapy and its impact on cardiovascular outcomes is unknown. The aim was to identify any association between timing of PCSK9i mAb initiation after a major adverse cardiovascular event (MACE) and the rate of subsequent MACE. Patient and Methods: A retrospective cohort study of adult patients in the United States with a MACE (myocardial infarction, stroke, unstable angina, or coronary revascularization) from January 1, 2017 to February 28, 2022 was conducted using administrative claims databases (index date = first observed MACE during this period). Patients were required to have ≥360 days of data visibility prior to (baseline period) and for ≥30 days after the index date (minimum, variable follow up period), and ≥1 prescription claim for PCSK9i mAb therapy on or after the index date. Subsequent MACE rates, time from index MACE to PCSK9i mAb initiation, and time to subsequent MACE were reported. Results: A total of 58,997 patients with ≥1 MACE were identified (mean age = 64 years; 58% male; median follow up=1,241 days). Over half of the patients did not initiate a PCSK9i mAb in the first year after the index MACE. Overall, 35% (n = 20,465) had ≥1 subsequent MACE. Compared to the period between index MACE and prior to PCSK9i mAb initiation, rates of subsequent MACE after PCSK9i mAb initiation were reduced in a time-dependent manner by 70% among patients who initiated PCSK9i mAb therapy within 30 days, 78% (31-90 days), 76% (91-180 days), 65% (181-360 days), and 42% (>360 days) after the index MACE. Those who initiated PCSK9i mAb within 30 days of the index MACE had longer median time to the first subsequent MACE (111 days) compared to patients who initiated at later times. Conclusion: This study provides evidence that earlier initiation of PCSK9i mAb therapy after a MACE appeared to be associated with longer time to a subsequent MACE. Patients without timely treatment are left at an unnecessarily elevated risk of further MACE.
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Sidelnikov et al. (2025) conducted a cohort in Prior Cardiovascular Events (MACE) (n=58,997). PCSK9 inhibitor monoclonal antibody (PCSK9i mAb) vs. Period between index MACE and prior to PCSK9i mAb initiation was evaluated on Rate of subsequent MACE (70% reduction (within 30 days), p=<0.0001). Initiation of PCSK9i mAb therapy within 30 days after a major adverse cardiovascular event reduced the rate of subsequent MACE by 70% compared to the period prior to initiation.
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