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October 19, 2000Journal of Medicinal ChemistryOpen Access

Resistance-Modifying Agents. 9. Synthesis and Biological Properties of Benzimidazole Inhibitors of the DNA Repair Enzyme Poly(ADP-ribose) Polymerase

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Authors

AWAlex W. WhiteSport WalesRARobert J. AlmassyCalifornia Institute of TechnologyACA. Hilary CalvertRaigmore Hospital

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White et al. (2000) studied this question.

synapsesocial.com/papers/6a10d3e439dd87f6d0ee6853https://doi.org/10.1021/jm000950v
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease.1995 · 781 citations
  2. 2New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening1990 · 9,831 citations
  3. 3Histone shuttle driven by the automodification cycle of poly(ADP‐ribose) polymerase1993 · 36 citations
  4. 4Poly (ADP-Ribose) synthetase. Separation and identification of three proteolytic fragments as the substrate-binding domain, the DNA-binding domain, and the automodification domain.1984 · 228 citations