Key result
Antihypertensive therapy requires careful selection of drugs based on comorbid conditions, as different classes and agents have unique pharmacologic characteristics and adverse effects.
Antihypertensive therapy should be individualized based on patient comorbidities and specific drug characteristics to optimize survival and minimize adverse effects.
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Supports comorbidity-guided antihypertensive selection; leaves open prospective trials defining optimal regimens.
Antihypertensive agents are commonly prescribed by physicians to prevent the long-term mortality from chronic hypertension. They are also given to improve survival in a number of conditions (eg, heart failure, coronary artery disease), independent of the effect on blood pressure. Several classes of antihypertensives are available with unique pharmacologic characteristics and adverse effects. Not all agents in the same class have identical effects, and careful selection of drugs based on the comorbid conditions is recommended.
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Reddy et al. (2015) conducted a review in Hypertension. Antihypertensive therapy was evaluated. Antihypertensive therapy requires careful selection of drugs based on comorbid conditions, as different classes and agents have unique pharmacologic characteristics and adverse effects.
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