Key result
RV pressure overload in rats triggers sex-dependent contractile and fibrotic responses despite comparable mechanoenergetic adaptation.
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Population
Rat model of increased right ventricular afterload
Comparison
Sex differences in right ventricular adaptation
Design
Animal model study
Answers are grounded in this paper and cite their sources.
Sex differences in right ventricular mechanical efficiency and energetic adaptation to increased right ventricular afterload were measured. Despite sex-dependent differences in contractile and fibrotic responses, right ventricular mechanoenergetic adaptation was comparable between the sexes, suggesting a homeostatic target.
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Cheng et al. (2022) studied this question. Right ventricular pressure overload in rats elicited sex-dependent contractile and fibrotic responses, but overall mechanoenergetic adaptation remained comparable between the sexes.
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