Why the study?
Female patients with pulmonary hypertension have better right ventricular adaptation than males, prompting investigation into the underlying mechanisms.
Does female sex improve right ventricular adaptation to pressure overload compared to male sex in a rat model?
Does female sex improve right ventricular adaptation to pressure overload compared to male sex in a rat model?
Female sex and estradiol confer a protective effect on right ventricular adaptation to pressure overload through enhanced angiogenesis mediated by sphingosine kinase-1.
May support sex-specific RV protection in overload models; leaves open translation to human pulmonary hypertension.
Female patients with pulmonary hypertension have better right ventricular adaptation compared with male. These sex differences were modeled in right heart failure susceptible Fischer CDF rat using pulmonary artery banding model. Preservation of right ventricular function in female rats is linked to better right ventricular angiogenic response that involves higher intrinsic angiogenic ability of female right ventricular endothelial cells together with the proangiogenic effects of female sex hormone estradiol through sphingosine kinase-1.
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Seelemann et al. (2025) studied this question.
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