The Sexual Dimorphism Associated with Pulmonary Hypertension Corresponds to a Fibrotic Phenotype

Q: What is the clinical evidence from this study?

Population: Pulmonary hypertension. Intervention: Female sex vs. Male sex. Primary outcome: Survival rate (p=<0.05).

Olga Rafikova; Ruslan Rafikov; Mary Louise Meadows; Archana Kangath; Danny Jonigk; Stephen M. Black

doi:10.1086/679724

February 10, 2015Pulmonary CirculationOpen Access

The Sexual Dimorphism Associated with Pulmonary Hypertension Corresponds to a Fibrotic Phenotype

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Structured PICO

P

Population

Male and female Sprague Dawley rats subjected to an occlusive-angioproliferative model of severe pulmonary hypertension and followed for 14 weeks.

E

Exposure

Single dose of SU5416 (20 mg/kg SC) followed by 4 weeks of hypoxia (10% O2) and 10 weeks of normoxia

C

Comparator

Vehicle injection and continuous normoxia for 14 weeks

O

Outcome

Survival rate, right ventricular peak systolic pressure, and right ventricular hypertrophy/fibrosissurrogate

Main Result

p-value: p=<0.05

Limitations

Animal models may not fully replicate human disease pathology
The mechanism behind the ability to maintain caveolin-1 expression in females is unresolved and requires further study

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Implication

In a rat model of pulmonary hypertension, female sex is associated with greater survival due to resistance to right ventricular fibrosis, despite similar elevations in pulmonary pressures.

Abstract

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Discussion

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Cite This Study

Rafikova et al. (2015) studied Pulmonary hypertension. Female sex vs. Male sex was evaluated on Survival rate (p=<0.05).

synapsesocial.com/papers/6a81b80e75f53d2468f1fea8 https://doi.org/10.1086/679724

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The Sexual Dimorphism Associated with Pulmonary Hypertension Corresponds to a Fibrotic Phenotype

Structured PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

The Sexual Dimorphism Associated with Pulmonary Hypertension Corresponds to a Fibrotic Phenotype

Structured PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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