Key result
Rhythm control therapy for atrial fibrillation was associated with lower long-term mortality after 5 years compared to rate control (HR 0.89; 95% CI 0.81-0.96), despite a small initial risk increase.
Authors
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Does not support changing AF rate vs rhythm practice; leaves open long-term survival benefit pending randomized confirmation.
Cohort (n=26,130)
Yes
Effect estimate: HR 0.89 (95% CI 0.81-0.96)
Ionescu‐Ittu et al. (2012) conducted a cohort in Atrial fibrillation (n=26,130). Rhythm control drugs vs. Rate control drugs was evaluated on Mortality (HR 0.89, 95% CI 0.81-0.96). Rhythm control therapy for atrial fibrillation was associated with lower long-term mortality after 5 years compared to rate control (HR 0.89; 95% CI 0.81-0.96), despite a small initial risk increase.
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