Key result
The T-A-A haplotype of COMT polymorphisms was associated with an increased risk for developing schizophrenia in a Greek population (OR 1.52; 95% CI 1.12-2.08; P=0.008).
Why the study?
Are COMT polymorphisms associated with schizophrenia in a Greek population?
Case-Control
Are COMT polymorphisms associated with schizophrenia in a Greek population?
Effect estimate: OR 1.52 (95% CI 1.12-2.08)
p-value: p=0.008
The T-A-A haplotype of COMT polymorphisms is associated with an increased risk of schizophrenia in a Greek population.
Association with schizophrenia risk in Greeks is hypothesis-generating; does not support clinical adoption of COMT testing.
Schizophrenia, a severe psychiatric condition, is characterized by disturbances of cognition, emotion, and social functioning. The disease affects almost 1% of world population. Recent studies evaluating the role of catechol-O-methyltransferase enzyme (COMT) polymorphisms in the pathogenesis of schizophrenia have resulted in ambiguous findings. The current study examined the association of schizophrenia with three COMT polymorphisms, namely, rs737865, rs4680, and rs165599 in a Greek population. There was no significant association between schizophrenia and any of the three SNPs examined. However, haplotype analysis showed that cases have higher frequency of the T-A-A haplotype, and participants with that haplotype were at increased risk for developing schizophrenia (OR = 1.52; CL : 1.12-2.08; P = 0.008). Furthermore, patients with schizophrenia displayed an excess of TC/AA/AA and the TT/AA/GA genotypes. Similarly a protective effect of TT/GG/GG and TT/GA/GG was suggested by our results.
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Kotrotsou et al. (2012) conducted a case-control in Schizophrenia. COMT polymorphisms (rs737865, rs4680, rs165599) vs. Controls was evaluated on Risk of developing schizophrenia (OR 1.52, 95% CI 1.12-2.08, p=0.008). The T-A-A haplotype of COMT polymorphisms was associated with an increased risk for developing schizophrenia in a Greek population (OR 1.52; 95% CI 1.12-2.08; P=0.008).
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