Key result
Endogenous fibrinolysis plays a crucial role in the pathogenesis of arterial thrombosis and presents novel ways to prevent and treat existing cardiovascular diseases.
This review highlights the role of endogenous fibrinolysis in the pathogenesis of arterial thrombosis and its potential for predicting cardiovascular outcomes.
Supports fibrinolysis assessment for risk prediction; leaves open whether targeted modulation improves arterial thrombosis outcomes.
The processes of thrombosis and coagulation are finely regulated by endogenous fibrinolysis maintaining healthy equilibrium. When the balance is altered in favour of platelet activation and/or coagulation, or if endogenous fibrinolysis becomes less efficient, pathological thrombosis can occur. Arterial thrombosis remains a major cause of morbidity and mortality in the world despite advances in medical therapies. The role endogenous fibrinolysis in the pathogenesis of arterial thrombosis has gained increasing attention in recent years as it presents novel ways to prevent and treat existing diseases. In this review article, we discuss the role of endogenous fibrinolysis in platelet thrombus formation, methods of measurement of fibrinolytic activity, its role in predicting cardiovascular diseases and clinical outcomes and future directions.
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Gue et al. (2017) conducted a review in Arterial thrombosis. Endogenous fibrinolysis was evaluated. Endogenous fibrinolysis plays a crucial role in the pathogenesis of arterial thrombosis and presents novel ways to prevent and treat existing cardiovascular diseases.
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