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July 1, 1993AJP Regulatory Integrative and Comparative Physiology

Acute phase response in exercise. III. Neutrophil and IL-1 beta accumulation in skeletal muscle

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Why the study?

Does 45 min of downhill running increase neutrophil and IL-1 beta accumulation in skeletal muscle in untrained men?

Population

9 untrained men (22-29 yr)

Comparison

45 min of downhill running vs Baseline (before exercise)

Design

Other

Follow-up

5 days

Authors

RFRoger A. FieldingUniversity of North Carolina at Chapel HillTMThomas ManfrediBoston UniversityWDWenxiang DingShanghai Jiao Tong University

Discussion

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Implication

Associates eccentric damage with IL-1β and neutrophils in untrained muscle; leaves open whether modulating this response affects recovery.

Structured PICO

Does 45 min of downhill running increase neutrophil and IL-1 beta accumulation in skeletal muscle in untrained men?

P
Population
9 untrained men (22-29 yr)
I
Intervention
45 min of downhill running (16% incline, 70% of maximum heart rate)
C
Comparator
Baseline (before exercise)
O
Outcome
Muscle interleukin-1 beta (IL-1 beta) accumulation, neutrophil accumulation, and Z-band damage measured via biopsy before, 45 min after, and 5 days after exercisesurrogate

Eccentric exercise induces ultrastructural damage to skeletal muscle that is associated with neutrophil infiltration and IL-1 beta accumulation.

Cite This Study

Fielding et al. (1993) studied this question.

synapsesocial.com/papers/6a10ea185e6663f9d264a665https://doi.org/10.1152/ajpregu.1993.265.1.r166
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Tissue damage, myocardial injury and recruitment of mature and banded neutrophils after high-intensity endurance exercise2025
  2. 2Musculoskeletal and Inflammatory Response to a Single Session of High-Volume Plyometric Exercise2026
  3. 3Differential inflammatory response of men and women subjected to an acute resistance exercise2021 · 20 citations
  4. 4Myofibers Express IL-6 after Eccentric Exercise2004 · 89 citations
  5. 5Biological maturation may contribute to difference in neutrophil mobilization and IL-8 responses following repeated sprint exercise in athletes: a quasi-experimental study2026