Brain Aging in African-Americans: The Atherosclerosis Risk in Communities (ARIC) Experience
Key result
Disproportionate rates of vascular risk factors, including diabetes, explain at least some of the observed racial disparities in brain aging and dementia between African-American and white participants.
Population
15,792 participants from four U.S. communities (biracial cohort from the ARIC study)
Design
Review
Follow-up
1987-1989 to 2011-2013
Authors
Discussion
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Member takes
Overview
Supports vascular risk management to address dementia disparities; leaves open prospective validation of causality.
Structured PICO
P
Population
15,792 participants from four U.S. communities (biracial cohort from the ARIC study)
O
Outcome
Racial disparities relating to stroke, subclinical brain infarction, leukoaraiosis, cognitive change, and dementia
Vascular risk factors, particularly diabetes, may differentially affect brain aging and contribute to racial disparities in stroke and dementia between African-American and white populations.
Cite This Study
Gottesman et al. (2015) conducted a review in Brain aging, dementia, and stroke (n=15,792). African-American race vs. White race was evaluated on Racial disparities in stroke, subclinical brain infarction, leukoaraiosis, cognitive change, and dementia. Disproportionate rates of vascular risk factors, including diabetes, explain at least some of the observed racial disparities in brain aging and dementia between African-American and white participants.