January 1, 2005
View Full PaperPrevalence of Moderate or Severe Left Ventricular Diastolic Dysfunction in Obese Persons with Obstructive Sleep Apnea
Key Result
Moderate or severe obstructive sleep apnea in obese patients was associated with a higher prevalence of moderate or severe LVDD compared to no or mild OSA (50% vs 0%, p<0.01).
Study Design
Type
Cross-Sectional (n=20)
Blinding
Blinded analysis
Structured PICO
Does moderate or severe obstructive sleep apnea increase the prevalence of moderate or severe left ventricular diastolic dysfunction in severely obese patients?
P
Population
20 obese patients (14 women, 6 men) prior to gastric bypass surgery, mean age 45 years, mean BMI 49+/-5 kg/m2, who had nocturnal polysomnography for obstructive sleep apnea (OSA).
I
Intervention
Moderate or severe obstructive sleep apnea (exposure)
C
Comparator
No or mild obstructive sleep apnea
O
Outcome
Prevalence of moderate or severe left ventricular diastolic dysfunction (LVDD) assessed by Doppler and tissue Doppler echocardiographysurrogate
Moderate or severe obstructive sleep apnea is associated with a significantly higher prevalence of moderate or severe left ventricular diastolic dysfunction in severely obese patients.
Main Result
Absolute Event Rate: 50% vs 0%
p-value: p=<0.01
Abstract
We investigated prior to gastric bypass surgery the prevalence of left ventricular diastolic dysfunction (LVDD) by Doppler and tissue Doppler echocardiography in 14 obese women and in 6 obese men, mean age 45 years, with a mean body mass index of 49+/-5 kg/m2 who had nocturnal polysomnography for obstructive sleep apnea (OSA). The Doppler and tissue Doppler echocardiographic data were analyzed blindly without knowledge of the clinical characteristics or whether OSA was present or absent. Of 20 patients, 8 (40%) had no OSA, 4 (20%) had mild OSA, and 8 (40%) had moderate or severe OSA. Moderate or severe LVDD was present in 4 of 8 patients (50%) with moderate or severe OSA and in none of 12 patients (0%) with no or mild OSA (p<0.01). Obese patients with moderate or severe OSA have a higher prevalence of moderate or severe LVDD than obese patients with no or mild OSA.