Key result
Cardiac magnetic resonance is more sensitive than echocardiography for early diagnosis of cardiac involvement in muscular dystrophies and has potential to improve prediction of long-term outcomes.
Why the study?
Cardiac manifestations often occur in muscular dystrophies, and the utility of CMR for early diagnosis, risk stratification, and guiding management needs review.
Does cardiac magnetic resonance (CMR) improve the assessment of myocardial involvement and risk stratification in patients with muscular dystrophies compared to echocardiography?
Does cardiac magnetic resonance (CMR) improve the assessment of myocardial involvement and risk stratification in patients with muscular dystrophies compared to echocardiography?
CMR provides superior sensitivity compared to echocardiography for early detection of cardiac involvement in muscular dystrophies, aiding in risk stratification and management.
May support earlier CMR in muscular dystrophy surveillance; leaves open need for prospective outcome validation.
Muscular dystrophies (MD) represent a heterogeneous group of rare genetic diseases that often lead to significant weakness due to progressive muscle degeneration. In many forms of MD, cardiac manifestations including heart failure, atrial and ventricular arrhythmias and conduction abnormalities can occur and may be a predominant feature of the disease. Cardiac magnetic resonance (CMR) can assess cardiac anatomy, global and regional ventricular function, volumes and mass as well as presence of myocardial inflammation, infiltration or fibrosis. The role for cardiac MRI has been well-established in a wide range of muscular dystrophies related cardiomyopathies. CMR is a more sensitive technique than echocardiography for early diagnosis of cardiac involvement. It has also great potential to improve the prediction of long-term outcome, particularly the development of heart failure and arrhythmic events; however it still has to be validated by longitudinal studies including large populations. This review will outline the utility of CMR in patients with muscular dystrophies for assessment of myocardial involvement, risk stratification, and in guiding therapeutic management.
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Lamacie et al. (2019) conducted a review in Muscular dystrophies. Cardiac magnetic resonance (CMR) vs. Echocardiography was evaluated. Cardiac magnetic resonance is more sensitive than echocardiography for early diagnosis of cardiac involvement in muscular dystrophies and has potential to improve prediction of long-term outcomes.
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