Key result
PCI in patients with severe aortic stenosis showed similar 30-day mortality compared to propensity-matched patients without aortic stenosis (4.3% vs 4.7%; HR 0.93; 95% CI 0.51-1.69; P=0.2).
Why the study?
Does percutaneous coronary intervention (PCI) increase 30-day mortality in patients with severe aortic stenosis compared to patients without aortic stenosis?
Cohort (n=762)
Does percutaneous coronary intervention (PCI) increase 30-day mortality in patients with severe aortic stenosis compared to patients without aortic stenosis?
Effect estimate: HR 0.93 (95% CI 0.51-1.69)
Absolute Event Rate: 4.3% vs 4.7%
p-value: p=0.2
PCI can be performed in patients with severe symptomatic aortic stenosis without an increased risk of 30-day mortality compared to matched patients without AS, though risk is significantly higher in those with LVEF ≤30% or STS score ≥10.
No takes yet. Share an insight, caveat, or question.
Supports PCI in severe AS without excess 30-day mortality; leaves open need for randomized confirmation in high-risk subgroups.
Goel et al. (2012) conducted a cohort in Severe aortic stenosis and coronary artery disease (n=762). Percutaneous coronary intervention (PCI) vs. PCI in propensity-matched patients without aortic stenosis was evaluated on 30-day mortality after PCI (HR 0.93, 95% CI 0.51-1.69, p=0.2). PCI in patients with severe aortic stenosis showed similar 30-day mortality compared to propensity-matched patients without aortic stenosis (4.3% vs 4.7%; HR 0.93; 95% CI 0.51-1.69; P=0.2).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: