Why the study?
Is obstructive sleep apnea associated with increased inflammatory biomarkers in nonobese patients with coronary artery disease?
Population
408 revascularized patients with coronary artery disease and preserved left ventricular ejection fraction…
Comparison
Obstructive sleep apnea defined by… vs No OSA and obese patients with CAD and OSA
Design
Cross-sectional
Key result
In nonobese patients with coronary artery disease, an oxygen desaturation index ≥5 events/h was independently associated with increased hs-CRP (OR 1.49; 95% CI 1.13-1.99) and IL-6.
Authors
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OSA-related desaturations associate with inflammation in nonobese CAD; hypothesis-generating for targeted interventions.
Cross-Sectional (n=408)
Is obstructive sleep apnea associated with increased inflammatory biomarkers in nonobese patients with coronary artery disease?
Effect estimate: OR 1.49 (hs-CRP) and OR 1.30 (IL-6) (95% CI 1.13-1.99 (hs-CRP) and 1.05-1.60 (IL-6))
Intermittent hypoxemia in obstructive sleep apnea is independently associated with increased inflammatory activity in nonobese patients with coronary artery disease.
Thunström et al. (2015) conducted a cross-sectional in Coronary Artery Disease and Obstructive Sleep Apnea (n=408). Obstructive sleep apnea (ODI ≥ 5 events/h) vs. No OSA (AHI < 5 events/h) was evaluated on Circulating levels of inflammatory biomarkers (hs-CRP, IL-6, IL-8, TNF-α) (OR 1.49 (hs-CRP) and OR 1.30 (IL-6), 95% CI 1.13-1.99 (hs-CRP) and 1.05-1.60 (IL-6)). In nonobese patients with coronary artery disease, an oxygen desaturation index ≥5 events/h was independently associated with increased hs-CRP (OR 1.49; 95% CI 1.13-1.99) and IL-6.