Obstructive sleep apnea (AHI ≥20) was independently associated with myocardial infarction (OR 2.0; 95% CI 1.0-3.8; p<0.05) in male patients evaluated for coronary artery disease.
Observational (n=289)
Is obstructive sleep apnea associated with coronary artery disease and myocardial infarction in male patients?
Obstructive sleep apnea is highly prevalent in patients with CAD, and moderate-to-severe OSA is independently associated with myocardial infarction.
Effect estimate: OR 2.0 (95% CI 1.0-3.8)
p-value: p=<0.05
STUDY OBJECTIVES: Obstructive sleep apnea (OSA) is associated with a range of cardiovascular sequelae and increased cardiovascular mortality. The aim of our study was to assess the prevalence of OSA in patients with symptomatic angina and angiographically verified coronary artery disease (CAD). In addition, we analyzed the association of OSA and other coronary risk factors with CAD and myocardial infarction. METHODS: Overnight non-laboratory-monitoring-system recordings for detection of OSA was performed in 223 male patients with angiographically verified CAD and in 66 male patients with exclusion of CAD. A logistic regression analysis was performed to assess associations between risk factors and CAD and myocardial infarction. RESULTS: CAD patients were found to have OSA in 30.5%, whereas OSA was found in control subjects in 19.7%. The mean apnea/hypopnea index (AHI) was significantly higher (p /=20 (OR 2.0; CI 1.0-3.8, p /=20) is independently associated with myocardial infarction. Thus, in the care of patients with CAD, particular vigilance for OSA is important.
Schäfer et al. (Fri,) conducted a observational in Coronary Artery Disease (n=289). Obstructive sleep apnea (OSA) vs. No OSA / Control subjects was evaluated on Myocardial infarction (OR 2.0, 95% CI 1.0-3.8, p=<0.05). Obstructive sleep apnea (AHI ≥20) was independently associated with myocardial infarction (OR 2.0; 95% CI 1.0-3.8; p<0.05) in male patients evaluated for coronary artery disease.