Key result
Severe minimal oxygen saturation and elevated heart rate linked to ~165% higher AMI odds.
Why the study?
Little was known regarding the quantification of sleep apnea- and hypoxemia-elicited heart rate response and its prognostic significance for cardiovascular risk.
Does the heart rate response to sleep apnea-induced hypoxemia associate with the occurrence of acute myocardial infarction in patients with suspected OSA?
Population
2,748 consecutive patients with suspected OSA
Comparison
OSA- and hypoxemia-elicited heart rate response and variability metrics
Design
Cross-sectional observational study
Authors
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Should not yet change OSA risk stratification; hypothesis-generating for prospective validation of predictive utility.
Cross-Sectional (n=2,748)
No
Does the heart rate response to sleep apnea-induced hypoxemia associate with the occurrence of acute myocardial infarction in patients with suspected OSA?
Effect estimate: OR 2.65 (95% CI 1.74-4.05)
p-value: p=<0.001
Elevated heart rate response to nocturnal hypoxemia in sleep apnea is significantly associated with an increased risk of acute myocardial infarction, suggesting its utility in cardiovascular risk stratification.
Huang et al. (2022) conducted a cross-sectional in Obstructive Sleep Apnea and Acute Myocardial Infarction (n=2,748). Severe minimal oxygen saturation (<90%) and elevated mean heart rate response (>73 bpm) vs. Minimal oxygen saturation ≥90% and mild heart rate response (≤73 bpm) was evaluated on Occurrence of acute myocardial infarction (AMI) (OR 2.65, 95% CI 1.74-4.05, p=<0.001). Patients with severe minimal oxygen saturation (<90%) and an elevated mean heart rate response (>73 bpm) had a 2.65-fold increased odds of acute myocardial infarction.
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