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October 1, 2012American Journal of EpidemiologyOpen Access

Being in the highest quartile of physical activity reduced the odds of high salt sensitivity of systolic blood pressure compared with the lowest quartile (OR 0.66; 95% CI 0.49-0.88).

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Why the study?

Does higher physical activity reduce salt sensitivity of blood pressure in individuals aged 16 or older?

Population

1,906 individuals aged 16 years or older living in rural northern China

Comparison

Highest quartile of usual physical activity… vs Lowest quartile of usual physical activity…

Design

Cohort

Follow-up

14 days

Key result

Being in the highest quartile of physical activity reduced the odds of high salt sensitivity of systolic blood pressure compared with the lowest quartile (OR 0.66; 95% CI 0.49-0.88).

Authors

CRCasey M. RebholzDGDongfeng GuJCJing Chen

Discussion

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Overview

May support activity assessment in salt-sensitive patients; leaves open whether increasing activity reduces BP salt sensitivity.

Study Design

Type

Observational (n=1,906)

Structured PICO

Does higher physical activity reduce salt sensitivity of blood pressure in individuals aged 16 or older?

P
Population
1,906 individuals aged 16 years or older living in rural northern China
I
Intervention
Highest quartile of usual physical activity (assessed at baseline via questionnaire) undergoing a 7-day low-sodium (51.3 mmol/day) followed by a 7-day high-sodium (307.8 mmol/day) dietary intervention
C
Comparator
Lowest quartile of usual physical activity undergoing the same dietary intervention
O
Outcome
Salt sensitivity of blood pressure (defined as mean BP change from the low-sodium intervention to the high-sodium intervention)surrogate

Main Result

Effect estimate: OR 0.66 (95% CI 0.49-0.88)

Absolute Event Rate: 3.96% vs 5.21%

p-value: p=0.003 for linear trend

Higher levels of physical activity are independently associated with reduced salt sensitivity of blood pressure, suggesting a targeted benefit for salt-sensitive individuals.

Cite This Study

Rebholz et al. (2012) conducted an observational in Salt sensitivity of blood pressure (n=1,906). High physical activity (highest quartile) vs. Low physical activity (lowest quartile) was evaluated on High salt sensitivity of systolic blood pressure (OR 0.66, 95% CI 0.49-0.88, p=0.003 for linear trend). Being in the highest quartile of physical activity reduced the odds of high salt sensitivity of systolic blood pressure compared with the lowest quartile (OR 0.66; 95% CI 0.49-0.88).

synapsesocial.com/papers/6a10ef2769716c70d0488efehttps://doi.org/10.1093/aje/kws266
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Interactions of Genetic Variants With Physical Activity Are Associated With Blood Pressure in Chinese: The GenSalt Study2011 · 20 citations
  2. 2The blood pressure–salt sensitivity paradigm: pathophysiologically sound yet of no practical value2016 · 23 citations
  3. 3Genetic Influences on the Response to Dietary Salt Reduction, Acute Salt Loading, or Salt Depletion in Humans1988 · 49 citations
  4. 4ASSOCIATION BETWEEN SALT SENSITIVITY AND BLOOD PRESSURE RESPONSE IN YOUNG ADULTS2025
  5. 5Clinical Modifiers of Salt Sensitivity: A Metaregression and Risk Translation Study2026