Key result
Higher major depression polygenic score linked to ~11% greater CAD risk per SD in females.
Why the study?
Cardiovascular health exhibits sex-based disparities due to under-researched female-specific risk factors, and findings on sex differences in psychiatric and cardiovascular comorbidity have been inconsistent.
Does genetic predisposition to psychiatric disorders differentially affect the risk of incident cardiovascular diseases in females compared to males?
Population
345,169 European-ancestry individuals in UK Biobank and 49,057 in BioVU
Comparison
Sex-specific genetic risk of major depression, schizophrenia, and bipolar disorder by polygenic scores
Design
Genetic epidemiology study with independent replication
Authors
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Should not yet inform sex-specific CVD risk assessment; leaves open causal mechanisms and generalizability in independent cohorts.
Cohort (n=345,201)
Yes
Does genetic predisposition to psychiatric disorders differentially affect the risk of incident cardiovascular diseases in females compared to males?
Effect estimate: OR 1.11 (95% CI 1.06 - 1.16)
p-value: p=5E-06
Genetic predisposition to major depression confers a significantly greater risk of incident cardiovascular diseases in females compared to males, independent of a clinical depression diagnosis.
Jiang et al. (2022) conducted a cohort in Cardiovascular disease and major depression (n=345,201). Polygenic score for major depression (PGSMD) vs. Lower genetic risk was evaluated on Incident coronary artery disease in females (OR 1.11, 95% CI 1.06 - 1.16, p=5E-06). A 1-standard-deviation increase in the polygenic score for major depression was associated with a 1.11-fold higher risk of incident coronary artery disease in females.
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