Key result
Multiple poor maternal CVH metrics during pregnancy linked to ~8-fold higher risk of poor offspring CVH.
Why the study?
Pregnancy may be a critical window to optimize maternal cardiovascular health and influence lifelong cardiovascular health in offspring.
Does better maternal cardiovascular health at 28 weeks' gestation improve offspring cardiovascular health at ages 10 to 14 years?
Population
2302 mother-child dyads across 9 field centers in 6 countries
Comparison
Maternal gestational CVH categories based on 5 metrics at 28 weeks gestation
Design
Multinational cohort study
Follow-up
Offspring ages 10 to 14 years
Authors
Loading...
Maternal CVH in pregnancy may influence offspring CVH in adolescence; leaves open causality and need for intervention trials.
Cohort (n=2,302)
Yes
Does better maternal cardiovascular health at 28 weeks' gestation improve offspring cardiovascular health at ages 10 to 14 years?
Effect estimate: RR 7.82 (95% CI 4.12-14.85)
Absolute Event Rate: 10.2% vs 2.6%
Better maternal cardiovascular health during pregnancy is strongly associated with better cardiovascular health in their offspring during early adolescence.
Perak et al. (2021) conducted a cohort in Cardiovascular health (n=2,302). Poor maternal gestational cardiovascular health (≥2 poor metrics) vs. Ideal maternal gestational cardiovascular health (all ideal metrics) was evaluated on Offspring having ≥2 poor cardiovascular health metrics at ages 10 to 14 years (RR 7.82, 95% CI 4.12-14.85). Having ≥2 poor maternal cardiovascular health metrics during pregnancy was associated with a higher risk of offspring having ≥2 poor metrics at ages 10-14 years (RR 7.82; 95% CI 4.12-14.85).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: