Key result
Endothelial dysfunction contributes to cardiovascular events and its assessment may help evaluate vulnerable patients.
Why the study?
Endothelial dysfunction is associated with cardiovascular events and significant morbidity and mortality, but its mechanisms and broader implications require further elucidation.
Assessment of endothelial function may be a valuable tool for identifying patients at high risk for future cardiovascular events.
Hypothesis-generating for endothelial dysfunction assessment in risk stratification; prospective validation required before clinical adoption.
A growing body of evidence suggests that endothelial dysfunction is associated with cardiovascular events.Endothelial dysfunction can be regarded as a syndrome that exhibits systemic manifestations associated with significant morbidity and mortality.The concept of endothelial dysfunction should be extended beyond the conduit vessels into the vascular wall and even to the bone marrow and the progenitor endothelial cells.The present review is focused on the potential underlying mechanism by which endothelial dysfunction may contribute to cardiovascular events.The assessment of endothelial function may emerge as an integral adjuvant test for evaluation of the vulnerable patients at risk for future cardiovascular events.
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Lerman et al. (2005) conducted a review in Endothelial dysfunction. Endothelial dysfunction was evaluated. Endothelial dysfunction contributes to cardiovascular events through systemic mechanisms, and its assessment may emerge as an integral test for evaluating vulnerable patients.
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