In hypertensive patients, a 1-unit increase in weight-adjusted waist index was significantly associated with a 57.98 mm/s increase in brachial-ankle pulse wave velocity.
Cross-Sectional (n=5,232)
Yes
Is weight-adjusted waist index associated with arterial stiffness in hypertensive patients?
Weight-adjusted waist index is positively associated with arterial stiffness in hypertensive patients across different BMI groups, suggesting it may be a useful marker for vascular risk.
Effect estimate: β 57.98 (95% CI 44.06-71.90)
p-value: p=<0.001
Objective Exploring the relationship between (weight-adjusted waist index) WWI and arterial stiffness (AS) in the total and different BMI populations among patients with hypertension. Methods This study enrolled 5232 hypertensive subjects, a subset of the China H-type Hypertension Registry Study. WWI was calculated as WC (cm) divided by the square root of weight (kg). Brachial-ankle pulse wave velocity (baPWV) was measured to determine AS. Results The mean WWI was 10.97 (0.78)cm/√kg. In multiple logistic analyses showed that there were significant dose-dependent association between WWI with baPWV in a dose-dependent manner in total population (β 57.98, 95% CI 44.06-71.90), and in different BMI group: group 1 (BMI18.5kg/m 2 ) (β 94.30, 95% CI 39.36-149.23), group 2 (18.5-23.9kg/m 2 ) (β 74.21, 95% CI 54.57-93.85), group 3 (≥24kg/m 2 ) (β 26.11, 95% CI 5.22-47.01). In stratified analysis, stronger associations between WWI and baPWV were observed in patients with higher BP or lower BMI. Sensitivity analysis by excluding patients treated with lipid-lowering agents did not change the association between WWI and baPWV. Conclusion For hypertensive patients, we found that WWI was positively associated with baPWV in different BMI groups. WWI might be considered as an intervening factor in preventing and treatment of AS, besides BP management.
Xiong et al. (Fri,) conducted a cross-sectional in Hypertension (n=5,232). Weight-adjusted waist index (WWI) was evaluated on Brachial-ankle pulse wave velocity (baPWV) (β 57.98, 95% CI 44.06-71.90, p=<0.001). In hypertensive patients, a 1-unit increase in weight-adjusted waist index was significantly associated with a 57.98 mm/s increase in brachial-ankle pulse wave velocity.