Idiopathic atrial fibrillation was associated with a significantly higher occurrence of cardiovascular disease compared with healthy controls in sinus rhythm (49% vs. 20%, P=0.006).
Cohort (n=86)
Does idiopathic atrial fibrillation increase the risk of developing cardiovascular disease compared to healthy sinus rhythm controls?
Patients with idiopathic atrial fibrillation have a significantly higher risk of developing cardiovascular disease at a younger age compared to healthy controls, suggesting a need for regular cardiovascular screening.
Tasa de eventos absoluta: 49% vs 20%
valor p: p=0.006
AIMS: Idiopathic atrial fibrillation (AF) may be an expression of as yet undetected underlying heart disease. We found it useful for clinical practice to study the long-term development of cardiovascular disease (CVD) in patients diagnosed with idiopathic AF. METHODS AND RESULTS: Forty-one consecutive idiopathic AF patients (56 ± 10 years, 66% male) were compared with 45 healthy control patients in permanent sinus rhythm. Patients were free of hypertension, antihypertensive and antiarrhythmic drugs, diabetes, congestive heart failure, coronary artery or peripheral vascular disease, previous stroke, thyroid, pulmonary and renal disease, and structural abnormalities on echocardiography. Baseline characteristics and echocardiographic parameters were equal in AF cases and controls. During a mean follow-up of 66 ± 11 months, CVD occurred significantly more often in idiopathic AF patients compared with controls (49 vs. 20%, P= 0.006). Patients with idiopathic AF were significantly younger at the time of their first CV event compared with controls (59 ± 9 vs. 64 ± 5 years, P= 0.027), and had more severe disease. Multivariable Cox regression analysis revealed that age, a history of AF, and echocardiographic left ventricular wall width were significant predictors of CVD development. CONCLUSION: Patients originally diagnosed with idiopathic AF develop CVD more often, at younger age, and with a more severe disease profile compared with healthy sinus rhythm control patients. The detection and treatment of CVD in an early stage could improve the prognosis of these patients. At present it seems prudent to regularly check idiopathic AF patients for the insidious development of CVD.
Weijs et al. (Tue,) conducted a cohort in Idiopathic atrial fibrillation (n=86). Idiopathic atrial fibrillation vs. Healthy controls in permanent sinus rhythm was evaluated on Development of cardiovascular disease (CVD) (p=0.006). Idiopathic atrial fibrillation was associated with a significantly higher occurrence of cardiovascular disease compared with healthy controls in sinus rhythm (49% vs. 20%, P=0.006).
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