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July 8, 2000BMJOpen Access

Percutaneous transluminal coronary angioplasty versus medical treatment for non-acute coronary heart disease: meta-analysis of randomised controlled trials

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Key result

Percutaneous transluminal coronary angioplasty reduced angina compared to medical treatment (RR 0.70; 95% CI 0.50-0.98) but increased the risk of coronary artery bypass grafting.

Why the study?

Does percutaneous transluminal coronary angioplasty improve outcomes compared to medical treatment in patients with non-acute coronary artery disease?

Population

1,904 patients with non-acute coronary artery disease from 6 RCTs

Comparison

Percutaneous transluminal coronary angioplasty vs Medical treatment

Design

Meta-analysis

Authors

HBHeiner C. BucherUniversity of Basel

Discussion

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Implication

PTCA may be considered for refractory angina in stable CAD; confirms higher CABG rates limit broader outcome benefits versus medical therapy.

Study Design

Type

Meta-Analysis (n=1,904)

Multicenter

Yes

Structured PICO

Does percutaneous transluminal coronary angioplasty improve outcomes compared to medical treatment in patients with non-acute coronary artery disease?

P
Population
1,904 patients with non-acute coronary artery disease from 6 RCTs (three of which included patients with multivessel disease and pre-existing myocardial infarction)
I
Intervention
Percutaneous transluminal coronary angioplasty
C
Comparator
Medical treatment
O
Outcome
Angina, fatal and non-fatal myocardial infarction, death, repeated angioplasty, and coronary artery bypass graftinghard clinical

Main Result

Effect estimate: RR 0.70 (95% CI 0.50-0.98)

In patients with non-acute coronary artery disease, percutaneous transluminal coronary angioplasty reduces angina compared to medical therapy but increases the need for subsequent coronary artery bypass grafting.

Limitations

  • Trials have not included enough patients for informative estimates of the effect of angioplasty on myocardial infarction, death, or subsequent revascularisation

Cite This Study

Heiner C. Bucher (2000) conducted a meta-analysis in Non-acute coronary artery disease (n=1,904). Percutaneous transluminal coronary angioplasty vs. Medical treatment was evaluated on Angina (RR 0.70, 95% CI 0.50-0.98). Percutaneous transluminal coronary angioplasty reduced angina compared to medical treatment (RR 0.70; 95% CI 0.50-0.98) but increased the risk of coronary artery bypass grafting.

synapsesocial.com/papers/6a10f3ee8102eb4b66eec39fhttps://doi.org/10.1136/bmj.321.7253.73
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Primary angioplasty versus intravenous thrombolysis for acute myocardial infarction2003 · 40 citations
  2. 2Multivessel versus Single Vessel Angioplasty in Non-ST Elevation Acute Coronary Syndromes: A Systematic Review and Metaanalysis2016 · 26 citations
  3. 3Clinical outcomes of stents versus balloon angioplasty in non-acute coronary artery disease A meta-analysis of randomized controlled trials2003 · 35 citations
  4. 4Comparison of Primary Coronary Angioplasty and Intravenous Thrombolytic Therapy for Acute Myocardial Infarction1997 · 1,007 citations
  5. 5Five-Year Follow-Up of the Medicine, Angioplasty, or Surgery Study (MASS)1999 · 24 citations