Key result
The CYP11B2 CC genotype was associated with a significantly greater nocturnal decline in systolic (P=0.0065) and diastolic (P=0.031) blood pressure compared to other genotypes in Japanese subjects.
Why the study?
Does the CYP11B2 C-344T polymorphism affect ambulatory blood pressure and nocturnal decline in blood pressure in the general Japanese population?
Population
802 subjects, aged 40 and over, in a Japanese community (Ohasama Study)
Comparison
CYP11B2 C-344T polymorphism (CC genotype) vs TC and TT genotypes
Design
Cross-sectional
Authors
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Supports CYP11B2 link to nocturnal BP dipping in Japanese adults; leaves open clinical utility pending prospective validation.
Cross-Sectional (n=802)
Does the CYP11B2 C-344T polymorphism affect ambulatory blood pressure and nocturnal decline in blood pressure in the general Japanese population?
p-value: p=0.0065 for systolic and 0.031 for diastolic decline
The CC genotype of the CYP11B2 C-344T polymorphism is associated with a greater nocturnal decline in blood pressure and a lower prevalence of previous cardiovascular disease in elderly or male Japanese subjects.
Matsubara et al. (2001) conducted a cross-sectional in General population (n=802). CYP11B2 C-344T polymorphism vs. Between genotypes (CC, CT, TT) was evaluated on 24 h ambulatory BP levels and nocturnal decline in BP (p=0.0065 for systolic and 0.031 for diastolic decline). The CYP11B2 CC genotype was associated with a significantly greater nocturnal decline in systolic (P=0.0065) and diastolic (P=0.031) blood pressure compared to other genotypes in Japanese subjects.
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