Mechanisms by Which Adenosine Restores Conduction in Dormant Canine Pulmonary Veins
Key result
Adenosine selectively hyperpolarizes canine pulmonary veins by increasing inward rectifier K+ current, restoring excitability and conduction in dormant veins.
Population
Canine pulmonary vein (PV) and left-atrial (LA) preparations
Comparison
Adenosine perfusion vs Baseline and nondormant PVs
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
Hypothesis-generating for adenosine in dormant pulmonary vein conduction; human trials needed before clinical adoption.
Structured PICO
P
Population
Canine pulmonary vein (PV) and left-atrial (LA) preparations
I
Intervention
Adenosine perfusion
C
Comparator
Baseline (before adenosine perfusion) and nondormant PVs
O
Outcome
Electrophysiological mechanisms of conduction restoration (action potential duration, resting potential, dV/dt(max), and ionic currents)surrogate
Adenosine restores conduction in dormant pulmonary veins after ablation by selectively hyperpolarizing the resting membrane potential via increased inward rectifier potassium current, which removes sodium channel inactivation.
Cite This Study
Datino et al. (2010) studied Dormant conduction after pulmonary vein isolation. Adenosine vs. Baseline / Left atrium / Nondormant pulmonary veins was evaluated on Resting potential and restoration of conduction. Adenosine selectively hyperpolarizes canine pulmonary veins by increasing inward rectifier K+ current, restoring excitability and conduction in dormant veins.