Key result
Ranolazine increased the ~15 mV difference in half-inactivation voltage of I(Na) between atrial and ventricular cells, proving more effective than lidocaine in terminating and preventing AF.
Why the study?
Does ranolazine or lidocaine selectively block atrial sodium channels and suppress atrial fibrillation in canine models?
Does ranolazine or lidocaine selectively block atrial sodium channels and suppress atrial fibrillation in canine models?
Ranolazine demonstrates striking atrial selectivity for use-dependent block of sodium channels, suggesting atrium-selective sodium channel block as a novel strategy for AF management.
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Hypothesis-generating for atrium-selective Na channel blockade in AF; leaves open translation to human therapy.
Burashnikov et al. (2007) studied Atrial fibrillation. Ranolazine vs. Lidocaine (2.1 to 21 micromol/L) was evaluated on Inactivation of peak sodium channel current (I(Na)) and electrophysiological effects. Ranolazine increased the ~15 mV difference in half-inactivation voltage of I(Na) between atrial and ventricular cells, proving more effective than lidocaine in terminating and preventing AF.
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