Key result
Persistent atrial fibrillation was associated with greater atrial sympathetic innervation than sinus rhythm, shown by higher tyrosine hydroxylase expression (0.45% vs 0.09%, P=0.02).
Why the study?
Is persistent atrial fibrillation associated with increased atrial sympathetic innervation compared to sinus rhythm in patients undergoing bypass surgery?
Observational (n=24)
Is persistent atrial fibrillation associated with increased atrial sympathetic innervation compared to sinus rhythm in patients undergoing bypass surgery?
Absolute Event Rate: 0.45% vs 0.09%
p-value: p=0.02
Patients with persistent atrial fibrillation have heightened atrial sympathetic innervation compared to those in sinus rhythm, suggesting autonomic remodeling contributes to the AF substrate.
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May support autonomic remodeling in persistent AF; hypothesis-generating and should not yet change practice.
Gould et al. (2006) conducted an observational in Persistent Atrial Fibrillation (n=24). Persistent atrial fibrillation vs. Sinus rhythm was evaluated on Tyrosine hydroxylase (TH) expression as a measure of sympathetic innervation (p=0.02). Persistent atrial fibrillation was associated with greater atrial sympathetic innervation than sinus rhythm, shown by higher tyrosine hydroxylase expression (0.45% vs 0.09%, P=0.02).
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