Key result
Prospective economic evaluation was demonstrated to be feasible to incorporate into phase III clinical trials for patients with severe congestive heart failure.
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Supports embedding economic evaluations in severe HF phase III trials; extends RCT methodology for integrated value assessment.
We present the prospective economic evaluation that served as a secondary endpoint for the FIRST study, a randomized international multicenter trial of patients with severe congestive heart failure. Although the clinical results of this study were disappointing, we demonstrated the feasibility of incorporating prospective economic evaluation in phase III clinical trials.
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Schulman et al. (1996) studied this question. Prospective economic evaluation was demonstrated to be feasible to incorporate into phase III clinical trials for patients with severe congestive heart failure.
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