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October 1, 1993Stroke

In vivo radiofrequency-based ultrasonic tissue characterization of the atherosclerotic plaque.

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Authors

MUM.P. UrbaniEPEugenio PicanoGPG Parenti

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Overview

Randomized trial evaluates tissue characterization of atherosclerotic plaques using ultrasonic imaging, indicating effectiveness in distinguishing plaque components.

Key Points

  • This study aims to assess the feasibility and accuracy of using ultrasonic imaging to evaluate atherosclerotic plaque composition.
  • 15 patients underwent carotid thromboendarterectomy with ultrasonic assessment of 70 discrete plaque sites.
  • Ultrasonic findings were correlated with histological analysis using hematoxylin-eosin and Mallory trichrome stains.
  • The integrated amplitude of the rectified radiofrequency signal was measured to determine the integrated backscatter index.
  • The integrated backscatter index values differentiated between fatty (-40.3 dB), fibrous (-23.8 dB), and calcified (-11.5 dB) plaque components (P < .01).
  • Intraluminal thrombiotic sites exhibited backscatter values indicating significant differences from fibrous and calcified components (P < .01).
  • The study demonstrates feasible operator-independent quantitative analysis of plaque structure in humans.

Cite This Study

Urbani et al. (1993) studied this question.

synapsesocial.com/papers/6a10fe44ed67694fb09fb6fahttps://doi.org/10.1161/01.str.24.10.1507
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