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January 1, 1998IEEE Transactions on Medical ImagingOpen Access

Comparison of histologically determined relative volume of soft materials with features from still images revealed a correlation coefficient of r = -0.42 (p = 0.002) for mean echogenicity, and r = -0.5 for Contrast.

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Why the study?

Does quantitative analysis of ultrasound B-mode images correlate with subjective classification and histological examination in patients scheduled for carotid endarterectomy?

Population

52 patients scheduled for carotid endarterectomy

Comparison

Quantitative analysis of ultrasound B-mode images vs Subjective classification of the ultrasound…

Design

Cross-sectional

Authors

JWJens E. WilhjelmMGM.-L.M. GrønholdtBWBritt Marie Wiebe

Discussion

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Overview

May limit clinical use of quantitative ultrasound for plaque composition; leaves open prospective validation of B-mode features.

Structured PICO

Does quantitative analysis of ultrasound B-mode images correlate with subjective classification and histological examination in patients scheduled for carotid endarterectomy?

P
Population
52 patients scheduled for carotid endarterectomy
I
Intervention
Quantitative analysis of ultrasound B-mode images (first- and second-order statistical features extracted from regions of the plaque in still ultrasound images from three orthogonal scan planes)
C
Comparator
Subjective classification of the ultrasound images obtained during scanning before operation and histological analysis of the surgically removed plaque
O
Outcome
Correlation of quantitative ultrasound features with subjective classification and histologically determined relative volume of soft materialssurrogate

Quantitative ultrasound features of carotid plaques show significant but weak correlations with histological composition, limiting their clinical utility for individual patient prediction.

Limitations

  • Correlation is probably not strong enough to be useful for clinical prediction of relative volume of soft materials for individual patients.

Cite This Study

Wilhjelm et al. (1998) studied this question.

synapsesocial.com/papers/6a7ce2b1ed0699a3c18d18c7https://doi.org/10.1109/42.746624
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ultrasonic tissue characterization of vulnerable carotid plaque: correlation between videodensitometric method and histological examination2006 · 44 citations
  2. 2Plaque Tissue Characterization and Classification in Ultrasound Carotid Scans: A Paradigm for Vascular Feature Amalgamation2012 · 53 citations
  3. 3Preoperative B-mode ultrasound plaque appearance compared with carotid endarterectomy specimen histology2000 · 53 citations
  4. 4Carotid Plaque Characterization with Contrast-Enhanced Ultrasound Imaging and its Histological Validation2010 · 11 citations
  5. 5In Vivo Ultrasonic Parametric Imaging of Carotid Atherosclerotic Plaque by Videodensitometric Technique1995 · 48 citations