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June 1, 2005Expert Review of Vaccines

Overcoming HIV diversity is likely to require the administration of a cocktail of envelope glycoprotein antigens to elicit a broad immune response capable of recognizing diverse HIV-1 isolates.

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Design

Review

Key result

Overcoming HIV diversity is likely to require the administration of a cocktail of envelope glycoprotein antigens to elicit a broad immune response capable of recognizing diverse HIV-1 isolates.

Authors

KSKaren S. SlobodMBMattia BonsignoriSBScott A. Brown

Discussion

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Overview

Does not yet alter HIV prevention practice; leaves open optimal polyvalent envelope combinations for broad-efficacy trials.

Structured PICO

I
Intervention
Cocktail vaccines (polyvalent envelope glycoprotein antigens)

A polyvalent cocktail approach to HIV vaccines may be necessary to overcome viral diversity and elicit broad B- and T-cell immune responses.

Cite This Study

Slobod et al. (2005) conducted a review in HIV. Cocktail of envelope glycoprotein antigens (polyvalent vaccines) vs. Single-envelope glycoprotein vaccines was evaluated. Overcoming HIV diversity is likely to require the administration of a cocktail of envelope glycoprotein antigens to elicit a broad immune response capable of recognizing diverse HIV-1 isolates.

synapsesocial.com/papers/6a10fe91cfa01e990d9ffcd0https://doi.org/10.1586/14760584.4.3.305
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