What question did this study set out to answer?

To evaluate recent advances in micro- and nanosystems engineered to navigate biological barriers and achieve controllable, targeted drug delivery for central nervous system disorders.

November 27, 2023The InnovationOpen Access

Micro/nanosystems for controllable drug delivery to the brain

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Authors

MTMingzhen TianCentre National de la Recherche Scientifique ZMZhichao MaCraft Group (China)GYGuang‐Zhong YangCardiac Imaging

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Implication

Review highlights advances in micro- and nanosystems for penetrating the blood-brain barrier in central nervous system disorders, indicating their potential for controllable and targeted therapies.

Key Points

To evaluate recent advances in micro- and nanosystems engineered to navigate biological barriers and achieve controllable, targeted drug delivery for central nervous system disorders.
Synthesized literature on anatomical and physiological barriers hindering brain drug administration, conventional therapeutic limitations, and clinical delivery challenges.
Evaluated cutting-edge microfluidic models used to replicate biomimetic microenvironments and assess drug transport kinetics.
Analyzed micro- and nanocarriers along with intraparenchymal micro-intervention systems, focusing on real-time guidance and closed-loop robotic control.
Microfluidic platforms reliably replicate the brain microenvironment, providing controlled in vitro validation for screening drug delivery dynamics.
Engineered micro- and nanocarriers facilitate increased payload transport across the blood-brain barrier using both systemic and localized intraparenchymal pathways.
Emerging robotic micro- and nanosystems demonstrate potential for precise autonomous navigation, real-time image guidance, and closed-loop drug release.

Cite This Study

Tian et al. (2023) studied this question.

synapsesocial.com/papers/6a10febad06b5b96589ffa75 https://doi.org/10.1016/j.xinn.2023.100548

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Implication

Review highlights advances in micro- and nanosystems for penetrating the blood-brain barrier in central nervous system disorders, indicating their potential for controllable and targeted therapies.

Micro/nanosystems for controllable drug delivery to the brain

Discussion

Member takes

Implication

Key Points

Cite This Study

Micro/nanosystems for controllable drug delivery to the brain

Discussion

Member takes

Implication

Key Points

Cite This Study

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