Key result
Spinal cord magnetization transfer ratio was lower in MS patients (median 30%) than healthy controls (median 33%, p<0.05), and combining MTR with cross-sectional area correlated with disability.
Why the study?
Do spinal cord magnetization transfer ratio (MTR) and cross-sectional area (CSA) correlate with neurologic disability in patients with multiple sclerosis?
Population
65 patients with multiple sclerosis and 9 healthy volunteers.
Comparison
Magnetic resonance imaging at 1.0 T to assess… vs Healthy volunteers
Design
Cross-sectional
Authors
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May support spinal cord MTR and CSA as MS biomarkers; hypothesis-generating and requires prospective validation before clinical adoption.
Observational (n=74)
Do spinal cord magnetization transfer ratio (MTR) and cross-sectional area (CSA) correlate with neurologic disability in patients with multiple sclerosis?
Absolute Event Rate: 30% vs 33%
p-value: p=<0.05
Spinal cord magnetization transfer ratio and cross-sectional area independently correlate with neurologic disability in patients with multiple sclerosis.
Nijeholt et al. (2000) conducted an observational in Multiple Sclerosis (n=74). Magnetic resonance imaging (1.0 T) vs. Healthy volunteers was evaluated on Spinal cord magnetization transfer ratio (MTR) (p=<0.05). Spinal cord magnetization transfer ratio was lower in MS patients (median 30%) than healthy controls (median 33%, p<0.05), and combining MTR with cross-sectional area correlated with disability.
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