TAVR in-hospital mortality varied significantly across US centers, with a patient's predicted odds of dying being 80% higher if treated at a hospital 1 SD above the mean versus 1 SD below (OR 1.8; 95% CrI 1.4%-2.2%).
Observational (n=22,248)
Yes
Does the hospital performing the procedure affect risk-adjusted in-hospital mortality in patients undergoing TAVR for aortic stenosis?
There is significant variation in risk-adjusted in-hospital mortality rates across US centers performing TAVR, highlighting the need for quality monitoring and feedback reporting.
Effect estimate: OR 1.8 (95% CI 1.4%-2.2%)
Background— The use of transcatheter aortic valve replacement (TAVR) to treat aortic stenosis in the United States is growing, yet little is known about the variation in procedural outcomes in community practice. We developed a TAVR in-hospital mortality risk model and used it to quantify variation in mortality rates across United States (US) TAVR centers. Methods and Results— We analyzed data from 22 248 TAVR procedures performed at 318 sites participating in the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry (November 2011 to October 2014). A Bayesian hierarchical model was developed to estimate hospital-specific risk-adjusted mortality rates adjusting for 40 patient baseline factors. A total of 1130 in-hospital deaths (5.1%) were observed. Reliability-adjusted risk-adjusted mortality rate estimates ranged from 3.4% to 7.7% with an interquartile range of 4.8% to 5.4%. A patient’s predicted odds of dying was 80% higher if treated by a hospital 1 standard deviation above the mean compared with a hospital 1 standard deviation below the mean (odds ratio =1.8; 95% credible interval, 1.4%–2.2%). Conclusions— Risk modeling of TAVR in-hospital mortality revealed variation in risk-adjusted mortality rates during the US early commercial experience. Transcatheter Valve Therapy Registry analyses using this model will support research, feedback reporting, and the identification of factors associated with quality.
O’Brien et al. (Thu,) conducted a observational in Aortic stenosis (n=22,248). Transcatheter aortic valve replacement (TAVR) vs. Hospital performance variation (1 SD above vs 1 SD below mean) was evaluated on In-hospital mortality (OR 1.8, 95% CI 1.4%-2.2%). TAVR in-hospital mortality varied significantly across US centers, with a patient's predicted odds of dying being 80% higher if treated at a hospital 1 SD above the mean versus 1 SD below (OR 1.8; 95% CrI 1.4%-2.2%).