Key result
In vitro enrichment of human blood with autologous HDL-C and LDL-C significantly increased erythrocyte aggregation compared to untreated controls, with HDL-C inducing a greater increase than LDL-C (P < 0.01).
Why the study?
Does enrichment with autologous lipoproteins affect erythrocyte aggregation in human blood samples?
Does enrichment with autologous lipoproteins affect erythrocyte aggregation in human blood samples?
In vitro enrichment of human blood with autologous HDL-C and LDL-C significantly increases erythrocyte aggregation compared to untreated controls.
The aim of this work was to evaluate in vitro the effect of autologous plasma lipoprotein subfractions on erythrocyte tendency to aggregate. Aliquots of human blood samples were enriched or not (control) with their own HDL-C, LDL-C, or VLDL-C fractions obtained from the same batch by density gradient ultracentrifugation. Plasma osmolality and erythrocyte aggregation index (EAI) were determined. Blood aliquots enriched with LDL-C and HDL-C showed significant higher EAI than untreated aliquots, whereas enrichment with VLDL-C does not induce significant EAI changes. For the same range of lipoprotein concentrations expressed as percentage of osmolality variation, the EAI variation was positive and higher in presence of HDL-C than upon enrichment with LDL-C (P < 0.01). Particle size, up to LDL diameter values, seems to reinforce erythrocyte tendency to aggregate at the same plasma osmolality (particle number) range of values.
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Saldanha et al. (2011) studied Erythrocyte aggregation. Enrichment with autologous HDL-C, LDL-C, or VLDL-C vs. Untreated aliquots (control) was evaluated on Erythrocyte aggregation index (EAI) (p=<0.01). In vitro enrichment of human blood with autologous HDL-C and LDL-C significantly increased erythrocyte aggregation compared to untreated controls, with HDL-C inducing a greater increase than LDL-C (P < 0.01).
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