Key result
Trabeculation extent shows no correlation with global or regional ejection fraction in LVNC.
Why the study?
Diagnostic criteria for LV noncompaction cardiomyopathy lack consensus and can be met by healthy individuals, indicating a need for differentiating diagnostic criteria.
Does the trabeculation rate or number of trabeculated segments correlate with left ventricular global and regional functions in patients with noncompaction cardiomyopathy?
Observational (n=65)
No
Does the trabeculation rate or number of trabeculated segments correlate with left ventricular global and regional functions in patients with noncompaction cardiomyopathy?
p-value: p=>0.05
There is no significant relationship between the extent of myocardial trabeculation and left ventricular dysfunction in noncompaction cardiomyopathy, limiting its diagnostic utility.
Trabeculation metrics should not guide LV function assessment in noncompaction; leaves open alternative mechanisms of dysfunction.
BACKGROUND: Left ventricular (LV) noncompaction cardiomyopathy is a rare cardiomyopathic subtype that has been recognized in recent years and is being diagnosed at an increased rate. There is no consensus regarding the diagnosis of the disease, and increased trabeculation rates that meet the existing diagnostic criteria may even be present in healthy asymptomatic people. This indicates that differentiating criteria for diagnosis are needed. AIM: To examine the increase in myocardial trabeculation and the change in left ventricular global and regional functions. METHODS: This retrospective study included 65 patients (28 females, 37 males) diagnosed with LV noncompaction cardiomyopathy who underwent cardiac magnetic resonance imaging between January 2011 and August 2016 and had a noncompacted/compacted myocardial thickness ratio of over 2.3 in more than one segment in the left ventricle. The distribution and ratios of trabeculations in apical, midventricular, and basal regions were examined in short-axis images obtained from cardiac magnetic resonance. In addition, by using short-axis cine images, regional ejection fraction (EF) and global EF were calculated using the Simpson method in the left ventricle at apical, basal, and midventricular levels. RESULTS: > 0.05). CONCLUSION: No global or regional relationship was observed between LV dysfunction and trabeculation rate or the number of trabeculated segments. This limits the usefulness of change in LV functions in the differentiation between normal and pathological trabeculation.
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Yıldırım et al. (2021) conducted an observational in Left ventricular noncompaction cardiomyopathy (n=65). Myocardial trabeculation was evaluated on Correlation between global/regional ejection fraction and the number of trabeculated segments or trabeculation ratio (p=>0.05). In patients with left ventricular noncompaction cardiomyopathy, there was no significant correlation between global or regional ejection fraction and the number of trabeculated segments or trabeculation ratio.
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