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July 1, 1996British Journal of PharmacologyOpen Access

The activation of P1‐ and P2‐purinoceptors in the guinea‐pig left atrium by diadenosine polyphosphates

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Population

Guinea-pig driven left atrium

Design

Preclinical

Authors

CHCharles H.V. HoyleState Research Center of the Russian FederationАЗА. У. ЗиганшинKazan State Medical UniversityJPJesús PintorUniversidad Complutense de Madrid

Discussion

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Implication

Hypothesis-generating for purinoceptor-mediated inotropy in models; leaves open translation to human cardiac therapies.

Structured PICO

P
Population
Guinea-pig driven left atrium
I
Intervention
Diadenosine polyphosphates (AP2A, AP3A, AP4A, AP5A), ATP, alpha, beta-methylene ADP, and 2-chloroadenosine (2-ClAd)
O
Outcome
Inotropic responsesurrogate

Diadenosine polyphosphates exert both negative and positive inotropic effects in the guinea-pig left atrium through distinct P1 and P2 purinoceptors.

Cite This Study

Hoyle et al. (1996) studied this question.

synapsesocial.com/papers/6a11085ee2199439c8f32d02https://doi.org/10.1111/j.1476-5381.1996.tb15536.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Blockade of adenosine receptors unmasks a stimulatory effect of ATP on cardiac contractility1993 · 37 citations
  2. 2Effects of chronic infusions of α‐trinositol on regional and cardiac haemodynamics in conscious rats1994 · 18 citations
  3. 3Suramin antagonizes responses to P2‐purinoceptor agonists and purinergic nerve stimulation in the guinea‐pig urinary bladder and taenia coli1990 · 317 citations
  4. 4Pre- and Postjunctional Effects of Diadenosine Polyphosphates in the Guinea-pig Vas Deferens1995 · 19 citations
  5. 5The adenosine 5',5''',P1,P4-tetraphosphate receptor is at the cell surface of heart cells1993 · 39 citations