Key result
Coffee and smoking both acutely inhibit FMD but differ in long-term vascular effects.
Why the study?
Many factors acutely reduce flow-mediated dilation, but it is unclear whether such short-term reductions consistently signal long-term vascular damage with repeated exposure.
Do acute reductions in flow-mediated dilation from caffeine and nicotine indicate long-term vascular damage?
Do acute reductions in flow-mediated dilation from caffeine and nicotine indicate long-term vascular damage?
Acute reductions in flow-mediated dilation caused by stimulants like caffeine and nicotine do not necessarily predict long-term vascular damage.
Answers are grounded in this paper and cite their sources.
Acute flow-mediated dilation inhibition by coffee or smoking does not indicate long-term damage; leaves open differential chronic vascular effects for prospective study.
Today, flow-mediated dilation (FMD) is a standardized test for the non-invasive assessment of vascular endothelial function in humans. The test is often used to assess the influence of various living conditions on the vascular system. Many factors have a short-term effect on FMD and reduce it. However, not every short-term FMD-reducing effect also signals long-term vascular damage with repeated exposure. The comparison between coffee consumption and smoking will be used to discuss that although both stimulants lead to comparable acute changes in vascular function, they differ in their long-term effects on the vascular system. Therefore, acute FMD effects cannot always be equated with long-term damaging effects.
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Störck et al. (2025) conducted a review in Vascular endothelial function. Coffee consumption and smoking was evaluated on Flow-mediated dilation (FMD). Although coffee consumption and smoking both acutely inhibit flow-mediated vasodilation, they differ in their long-term effects on the vascular system.
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