August 1, 1993American Journal of Psychiatry
Anger attacks in unipolar depression, Part 1: Clinical correlates and response to fluoxetine treatment
Why the study?
Does fluoxetine reduce anger attacks in medication-free outpatients with major depression?
Population
127 medication-free outpatients with major depression
Design
Cohort
Follow-up
8 weeks
Authors
Discussion
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Member takes
Implication
Fluoxetine may reduce anger attacks in depressed outpatients; this cohort finding is hypothesis-generating and requires randomized confirmation before practice change.
Structured PICO
Does fluoxetine reduce anger attacks in medication-free outpatients with major depression?
P
Population
127 medication-free outpatients with major depression
I
Intervention
Fluoxetine 20 mg/day for 8 weeks
O
Outcome
Reduction in anger attacks and hostility measures (Anger Attacks Questionnaire, Hamilton Rating Scale for Depression, Symptom Questionnaire, Cook-Medley Hostility Scale)patient reported
Fluoxetine treatment appears beneficial in reducing anger attacks and hostility in a subgroup of highly irritable and hostile depressed patients.
Cite This Study
Fava et al. (1993) studied this question.