Why the study?
Does early thrombolytic therapy reduce hospital mortality in patients with acute myocardial infarction?
Population
Patients with acute myocardial infarction
Comparison
Early thrombolytic therapy vs Placebo
Design
Review
Authors
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May inform historical reperfusion context; leaves open applicability to contemporary PCI-dominant practice.
Does early thrombolytic therapy reduce hospital mortality in patients with acute myocardial infarction?
Early thrombolytic therapy significantly reduces hospital mortality and limits infarct size in patients with acute myocardial infarction, with an acceptable safety profile regarding intracranial bleeding.
Maarten L. Simoons (1989) studied this question.
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