Key result
High salt diet increases myocardial GLUT4 expression to ~27% in rats, potentially altering substrate transport.
Why the study?
Altered substrate transport protein expression is central to the effect of insulin resistance on cardiac metabolism, prompting investigation of the comparative effects of high-fat, high-sucrose, and salt-induced insulin resistance on cardiac FATP and GLUT4 expression.
Does diet-induced insulin resistance alter cardiac GLUT4 and FATP/CD36 expression in rats?
Does diet-induced insulin resistance alter cardiac GLUT4 and FATP/CD36 expression in rats?
Salt-induced insulin resistance, rather than just caloric excess, plays a significant role in altering myocardial substrate transport protein expression (GLUT4 and FATP/CD36) in rats.
Answers are grounded in this paper and cite their sources.
Does not support clinical dietary changes; leaves open salt's role in myocardial substrate transport during insulin resistance.
Background Altered substrate transport protein expression is central to the effect of insulin resistance on cardiac metabolism. The present study was thus designed to investigate the comparative effects of high fat, high sucrose and salt-induced IR on cardiac expression of fatty acid transporter (FATP) and glucose transporter (GLUT4) in rats. Results Rats fed with high fat, high sucrose and salt diets developed impaired glucose tolerance ( p > 0.05) and hyperinsulinemia ( p < 0.05) compared with control group. Myocardial glucose transporter expression was significantly increased ( p < 0.001 for salt-induced IR; p < 0.01 for sucrose-induced IR; p < 0.01 for fat-induced IR) across all IR groups compared with control. Fatty acid transporter expression was also increased ( p < 0.001) in high salt diet-induced IR rats, and high fat diet-induced IR rats ( p < 0.05). Conclusions Our results demonstrate that salt and not caloric excess has a potential role in IR alteration of myocardial substrate transport protein expression in the rat.
No takes yet. Share an insight, caveat, or question.
Afolabi et al. (2022) studied Diet-induced insulin resistance (n=40). High salt diet vs. Normal diet was evaluated on Myocardial GLUT4 expression (% expression) (p=<0.001). A high salt diet significantly increased myocardial GLUT4 expression to 26.67% compared to 4.30% in control rats, demonstrating that salt plays a potential role in altering myocardial substrate transport.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: