Randomized trial demonstrates elimination of Moloney sarcoma in rats, suggesting potential immunotherapy approaches.
Key Points
The study aims to assess the in vivo elimination of Moloney sarcoma (MST) using immune spleen cells from immunized rats.
BN rats were immunized with MST or a chemical-induced fibrosarcoma (BC5) to obtain immune spleen cells.
Spleen cells were tested in vitro using a 51Cr release assay and then infused into x-rayed and nonirradiated BN recipients bearing subcutaneous MST or BC5.
Control spleen cells from untreated BN rats were also tested in vitro and in vivo.
Spleen cells immune to MST after culture with MSTMit eliminated established MST in vivo in less than 35 days.
Cytotoxicity generation in vitro correlated with successful MST elimination by cultured immune spleen cells.
MST immune spleen cells did not impact the growth of BC5, indicating specificity in immune response.
Cite This Study
Fernández‐Cruz et al. (1979) studied this question.