Population
60 cell lines of the National Cancer Institute preclinical antitumor drug discovery screen, purified…
Comparison
Anthrapyrazoles (DuP 941/Losoxantrone and DuP 937) vs Other topoisomerase II inhibitors
Design
Preclinical
Authors
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May offer less cardiotoxic topoisomerase II inhibitors; leaves open human cardiovascular safety confirmation.
Anthrapyrazoles are potent topoisomerase II inhibitors with a mechanism of action similar to mitoxantrone, potentially offering a less cardiotoxic alternative to anthracyclines.
Leteurtre et al. (1994) studied this question.
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