Key result
Metabolic syndrome was associated with higher depression scores, with elevated blood glucose in men and central obesity in women driving the association.
Why the study?
Is metabolic syndrome associated with self-perceived depression in adults?
Cross-Sectional (n=416)
No
Is metabolic syndrome associated with self-perceived depression in adults?
Elevated plasma glucose in men and central obesity in women are associated with self-perceived depression, highlighting a co-occurrence that warrants clinical attention.
Answers are grounded in this paper and cite their sources.
May warrant depression screening in metabolic syndrome; hypothesis-generating and should not yet change practice.
OBJECTIVE: To study the association between metabolic syndrome (MetS) and self-perceived depression. DESIGN: A cross-sectional community-based study. SETTING: Semi-rural community of Lapinlahti in eastern Finland in 2005. SUBJECTS: A total of 416 subjects in eight adult birth cohorts (55%) with complete Beck Depression Inventory (BDI-21) questionnaire data. MAIN OUTCOME MEASURES: The values of the 21 BDI items and the BDI-21 total score with a cut-off point of 14/15 were used to study the association between MetS and depression. National Cholesterol Education Programme (NCEP) 2005 criteria were used for MetS classification. RESULTS: The total BDI-21 score was significantly higher in the subjects with MetS than in the subjects without MetS (p=0.020). Men with MetS were significantly worse off than men without MetS in the BDI-21 items of irritability (p=0.008), work inhibition (p=0.008), fatigability (p=0.037), weight loss (p=0.045), and loss of libido (p=0.014), while women were only so on the item of loss of libido (p=0.007). In a logistic regression analysis using a BDI-21 cut-off point of 14/15 adjusted for age, marital status, vocational education, and working status, significant association was retained between perceived depression and elevated blood glucose among men (OR=1.697) and large waist circumference among women (OR=1.066). CONCLUSION: Elevated plasma glucose in men and central obesity in women are associated with self-perceived depression. This co-occurrence deserves attention in clinical practice.
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Miettola et al. (2008) conducted a cross-sectional in Metabolic syndrome and depression (n=416). Metabolic syndrome vs. Without metabolic syndrome was evaluated on BDI-21 total score and cut-off point of 14/15 (OR 1.697 (men, glucose); OR 1.066 (women, waist), p=0.020). Metabolic syndrome was associated with higher depression scores, with elevated blood glucose in men and central obesity in women driving the association.
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